The Pain of Fibromyalgia and Depression in Women

The reported that research from Sweden has shed some light as to why women are more likely to suffer from depression, chronic pain (CPS) and fibromyalgia syndrome (FMS) than men.  Also, the same study discovered why women are prone to depression and mood swings from pre-menstrual syndrome (PMS) and post-partum depression.

Serotonin production, re-absorption and normal levels in many women are not sufficient and wreak havoc on the mind and bodies of those affected. The effect on female hormones is broadly significant. Serotonin, known as the ‘happy hormone,’ plays a significant role in pain management.

Chronic or clinical depression can be the causation of chronic pain. Chronic pain can lead to chronic or clinical depression, so healthy levels of serotonin play a significant role in managing depression and chronic pain.

Those with fibromyalgia may suffer depression from chronic pain so a healthy level of serotonin is essential to manage fibromyalgia. Medications such as serotonin and norepinephrine reuptake inhibitors SNRI) such as Savella, Prozac and Cymbalta are widely known to manage hormone levels and treat chronic central nervous system (CNS) pain disorders. Other medications such as Neurontin are beneficial for peripheral pain.

The two together can be a one-two-three punch to solve the lack of serotonin, help resolve CNS  and peripheral pain and if one medication delivers poor results or unacceptable side effects, trying others can yield desired results.

As with SNRI’s, one TCA is not the same as the next so sometimes, experimenting is key to treatment. TCA’s are; amitriptyline, amoxapine, desipramine,, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine.


4 thoughts on “The Pain of Fibromyalgia and Depression in Women

  1. Invisibly Me says:

    There’s definitely a big knock-on effect for us with fibro, and the various treatments can be a little confusing but important to navigate incase they can ease the symptoms and address additional issues, such as depression like you mentioned. Thanks for sharing! 🙂


    • cherished79 says:

      Sorry for the delay in replying to your comment. Fibro is one of those invisible illnesses where it wasn’t taken very seriously by insurance companies years ago, but I think they believe women more now (I hope). Doctor’s were also stumped by these ‘aches and pain’ complaints by women, but now there is a name for this chronic illness and research shows there is a connection to depression. Hooray! Wake up, people. Thanks for stopping by. 🙂


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